Reaction of S-geranyl-2-thiouracil modified oligonucleotides with alkyl amines leads to the N2-alkyl isocytosine derivatives-Reference-Cited by-同舟云学术

Reaction of S-geranyl-2-thiouracil modified oligonucleotides with alkyl amines leads to the N2-alkyl isocytosine derivatives

Published:2017 Issue:25 Volume:15 Page:5332-5336
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Leszczynska Grazyna¹²³⁴^ORCID,Sadowska Klaudia¹²³⁴^ORCID,Sierant Malgorzata⁵⁶⁷⁸⁴^ORCID,Sobczak Milena⁵⁶⁷⁸⁴^ORCID,Nawrot Barbara⁵⁶⁷⁸⁴^ORCID,Sochacka Elzbieta¹²³⁴^ORCID

Affiliation:

1. Institute of Organic Chemistry

2. Lodz University of Technology

3. 90-924 Lodz

4. Poland

5. Department of Bioorganic Chemistry

6. Centre of Molecular and Macromolecular Studies

7. Polish Academy of Sciences

8. 90-363 Lodz

Abstract

The yield of the synthesis ofS-geranylated oligomers depends on the alkaline conditions of oligomer deprotection; a routinely used alkyl amine protocol deliversN2-alkylisocytosine-modified side products.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB01012E

Reference14 articles.

1. Distribution and frequencies of post-transcriptional modifications in tRNAs

2. Discovery and biological characterization of geranylated RNA in bacteria

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5. S-Geranyl-2-thiouridine wobble nucleosides of bacterial tRNAs; chemical and enzymatic synthesis ofS-geranylated-RNAs and their physicochemical characterization

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