Analysis of the effect of cations on protein conformational stability using solid-state nanopores

Author:

Zhu Libo1ORCID,Wu Hongwen2,Xu Zhengyuan1,Guo Lanying1,Zhao Jinsong1

Affiliation:

1. School of Medical Imaging, Wannan Medical College, Wuhu, 241002, China

2. Jiangxi Institute of Respiratory Disease, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China

Abstract

This work studied the cations (Li+ and Na+) effect on the conformational stability of negative charged BSA, and provides a novel analysis method for the conformational changes of proteins in situ.

Funder

National Natural Science Foundation of China

Anhui Department of Education

Publisher

Royal Society of Chemistry (RSC)

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