A facile approach to tryptophan derivatives for the total synthesis of argyrin analogues-Reference-Cited by-同舟云学术

A facile approach to tryptophan derivatives for the total synthesis of argyrin analogues

Published:2014 Issue:48 Volume:12 Page:9764-9768
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Chen Chou-Hsiung¹²³⁴,Genapathy Sivaneswary¹²³⁴,Fischer Peter M.¹²³⁴,Chan Weng C.¹²³⁴

Affiliation:

1. School of Pharmacy

2. Centre for Biomolecular Sciences

3. University of Nottingham

4. Nottingham NG7 2RD, UK

Abstract

Utilising a chiral auxiliary-facilitated Strecker amino acid synthesis strategy, indole-substituted (S)-tryptophans have been obtained from corresponding indoles; the former in turn were used for the synthesis of a potent antibacterial agent, argyrin and its analogues.

Funder

University Of Nottingham

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB02107J

Reference30 articles.

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2. Argyrins, Immunosuppressive Cyclic Peptides from Myxobacteria. I. Production, Isolation, Physico-chemical and Biological Properties.

3. Antibiotics A21459 A and B, New Inhibitors of Bacterial Protein Synthesis. II. Structure Elucidation.