Multi-functional derivatization of amine, hydroxyl, and carboxylate groups for metabolomic investigations of human tissue by electrospray ionization mass spectrometry
Author:
Affiliation:
1. Department of Chemistry
2. Saint Louis University
3. St louis MO
4. USA
5. Cardiovascular Comprehensive Care Center
Abstract
Novel two step-derivatization of hydroxyl, amine, and carboxylate groups for expanding the metabolomics toolbox.
Funder
National Institute of General Medical Sciences
Publisher
Royal Society of Chemistry (RSC)
Subject
Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/AN/C8AN00490K
Reference33 articles.
1. Metabolomics and Metabolic Diseases: Where Do We Stand?
2. A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance
3. Metabolomics Applied to Diabetes Research
4. Emerging applications of metabolomics in drug discovery and precision medicine
5. Metabolomics for clinical use and research in chronic kidney disease
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