Pd-catalyzed enantioselective [4 + 4] dipolar cycloaddition of aliphatic 1,4-dipoles with azadienes to access eight-membered N-heterocycles-Reference-Cited by-同舟云学术

Pd-catalyzed enantioselective [4 + 4] dipolar cycloaddition of aliphatic 1,4-dipoles with azadienes to access eight-membered N-heterocycles

Published:2023 Issue:18 Volume:10 Page:4698-4702
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Chen Gen-Hui¹,Ye Ying¹,Zhang De-Xin¹,Li Hong-Jiao¹,Zhang Ning¹,Liang Guo-Juan¹,Zhang Dong¹,Zhou Jing¹^ORCID,Zhou Hui¹^ORCID

Affiliation:

1. Chongqing Research Center for Pharmaceutical Engineering, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China

Abstract

A novel asymmetric [4 + 4] dipolar cycloaddition of aliphatic 1,4-dipoles with azadienes was developed to construct chiral benzofuran- and indene-fused eight-membered N-heterocycles in good yields and excellent stereoselectivities.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Chongqing

Chongqing Municipal Education Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D3QO01089A

Reference38 articles.

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5. Catalytic Asymmetric Construction of a 1,2,4-Benzotriazepine Skeleton via Diastereo- and Enantioselective Decarboxylative [4 + 3] Cyclization

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