Synthesis and structure–activity relationship of novel thiazole aminoguanidines against MRSA and Escherichia coli

Author:

Yang Ping1ORCID,Liu Hui-Zhong1,Wang Ying-Si1,Qi Hong1,Wang Ling-Ling1ORCID,Wang Bei-Bei1,Xie Xiao-Bao1ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangdong Detection Centre of Microbiology, Guangzhou 510070, China

Abstract

Increasing molecular flexibility improves the performance of thiazole aminoguanidines against drug-resistant bacteria and Gram-negative bacteria.

Funder

National Natural Science Foundation of China

Guangdong Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Reference30 articles.

1. World Antimicrobial Awareness Week 2022 , https://www.who.int/westernpacific/news-room/events/detail/2022/11/18/western-pacific-events/world-antimicrobial-awareness-week-2022

2. U.S. Antibiotic Awareness Week is November 18–24 , 2023 , https://www.cdc.gov/antibiotic-use/week/get-involved.html

3. World Health Organization , Antibacterial Agents in Clinical Development , World Health Organization , 2017 , https://www.who.int/publications/i/item/antibacterial-agents-in-clinical-development

4. Undecaprenyl Diphosphate Synthase Inhibitors: Antibacterial Drug Leads

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