Cisplatin nephrotoxicity in male beagle dogs: next-generation protein kidney safety biomarker tissue expression and related changes in urine-Reference-Cited by-同舟云学术

Cisplatin nephrotoxicity in male beagle dogs: next-generation protein kidney safety biomarker tissue expression and related changes in urine

Published:2016 Issue:4 Volume:5 Page:1202-1215
ISSN:2045-452X
Container-title:Toxicology Research
language:en
Short-container-title:Toxicol. Res.

Author:

McDuffie J. E.¹²³⁴⁵,Chen Y.¹²³⁴⁵,Ma J. Y.¹²³⁴⁵,Lee S.¹²³⁴⁵,Lynch K. M.⁶⁷⁸⁵,Hamlin D. M.⁹¹⁰¹¹⁵,Nguyen L.¹²³⁴⁵,Rizzolio M.¹²³⁴⁵,Sonee M.¹²³¹²⁵,Snook S.¹²³⁴⁵

Affiliation:

1. Discovery Sciences

2. Janssen Research & Development

3. L.L.C.

4. San Diego

5. USA

6. Department of Safety Assessment

7. GlaxoSmithKline

8. King of Prussia

9. Investigative Toxicology

10. Eli Lilly & Co.

11. Indianapolis

12. Spring House

Abstract

In dogs, CDDP induced corticomedullary tubular lesions [A.]; clusterin (CLU) staining in damaged medullary tubules [B.]; and elevated urinary CLU [C.]. Baseline CLU was detected from Control dogs [A. and C.].

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://pubs.rsc.org/en/content/articlepdf/2016/TX/C5TX00497G

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