Mapping the binding site topology of amyloid protein aggregates using multivalent ligands-Reference-Cited by-同舟云学术

Mapping the binding site topology of amyloid protein aggregates using multivalent ligands

Published:2021 Issue:25 Volume:12 Page:8892-8899
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Sanna Elena¹²³⁴,Rodrigues Margarida¹²³⁴,Fagan Steven G.⁵⁶²⁷⁴,Chisholm Timothy S.¹²³⁴^ORCID,Kulenkampff Klara¹²³⁴,Klenerman David¹²³⁴,Spillantini Maria Grazia⁵⁶²⁷⁴,Aigbirhio Franklin I.⁸⁹²⁴^ORCID,Hunter Christopher A.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Cambridge

3. Cambridge CB2 1EW

4. UK

5. Department of Clinical Neurosciences

6. Clifford Allbutt Building

7. Cambridge

8. Department of Clinical Neuroscience

9. Wolfson Brain Imaging Centre

Abstract

Multivalent ligands offer a powerful approach to obtain high affinity reagents to bind the aggregates that form in neurodegenerative disease. Selectivity for different proteins was achieved by using different linkers to connect the head groups.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC01263K

Reference36 articles.

1. A new era for understanding amyloid structures and disease

2. The binding of thioflavin-T to amyloid fibrils: localisation and implications

3. Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression

4. Technetium-99m Labeled Pyridyl Benzofuran Derivatives as Single Photon Emission Computed Tomography Imaging Probes for β-Amyloid Plaques in Alzheimer’s Brains

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