Catalyst-free synthesis of α,α-disubstituted carboxylic acid derivatives under ambient conditions via a Wolff rearrangement reaction-Reference-Cited by-同舟云学术

Catalyst-free synthesis of α,α-disubstituted carboxylic acid derivatives under ambient conditions via a Wolff rearrangement reaction

Published:2021 Issue:24 Volume:8 Page:6916-6922
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Ji Xin¹,Zhang Zhikun¹,Wang Yuzhu¹,Han Yazhe¹,Peng Huiling¹,Li Fangzhu¹,Liu Lu¹²^ORCID

Affiliation:

1. School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, P. R. China

2. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062, P. R. China

Abstract

Herein, a hexafluoroisopropanol (HFIP)-promoted Wolff rearrangement reaction was developed, delivering various α,α-disubstituted carboxylic acid derivatives in good to excellent yields.

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/QO/D1QO01265G

Reference101 articles.

1. 6-Chloro-5-cyclohexylindan-l-carboxylic Acid (TAI-284), a New Antiinflammatory Agent

2. Soft drugs. 3. A new class of anticholinergic agents