Synthesis and SAR of 2,4-diaminopyrimidines as potent c-jun N-terminal kinase inhibitors-Reference-Cited by-同舟云学术

Synthesis and SAR of 2,4-diaminopyrimidines as potent c-jun N-terminal kinase inhibitors

Published:2012 Issue:2 Volume:3 Page:238-243
ISSN:2040-2503
Container-title:Med. Chem. Commun.
language:en
Short-container-title:Med. Chem. Commun.

Author:

Song Xinyi,He Yuanjun,Koenig Marcel,Shin Youseung,Noel Romain,Chen Weimin,Ling Yuan Yuan,Feurstein Daniel,Lin Li,Ruiz Claudia H.,Cameron Michael D.,Duckett Derek R.,Kamenecka Theodore M.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2012/MD/C1MD00219H

Reference23 articles.

1. pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine.

2. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

3. Affinity-purified c-Jun amino-terminal protein kinase requires serine/threonine phosphorylation for activity.

4. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

5. The stress-activated protein kinase subfamily of c-Jun kinases

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Diversification Via Coupling Reactions and Biological Activities of Pyrimidine Derivatives;ChemistrySelect;2023-12-15

2. Inhibitors of c-Jun N-Terminal Kinase 3;Proteinkinase Inhibitors;2020

3. Discovery of new JNK3 inhibitory chemotypes via QSAR-Guided selection of docking-based pharmacophores and comparison with other structure-based pharmacophore modeling methods;Journal of Molecular Graphics and Modelling;2019-09

4. Brain penetrant kinase inhibitors: Learning from kinase neuroscience discovery;Bioorganic & Medicinal Chemistry Letters;2018-06

5. 2-Aminopyrimidines;Privileged Structures in Drug Discovery;2018-03-09