Acyl-caged rhodamines: photo-controlled and self-calibrated generation of acetyl radicals for neural function recovery in early AD mice

Author:

Luo Xiao1ORCID,Zhang Zhonghui1,Wang Jie2,Wang Xueli3,Zhang Yani4,Chen Jinquan3ORCID,Ge Guangbo4ORCID,Yang Wen2,Qian Xuhong15,Tian Yang1ORCID,Yang Youjun5ORCID

Affiliation:

1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Dongchuan Road 500, Shanghai 200241, China

2. Department of Molecular and Cellular Biochemistry, School of Medicine, Shanghai Jiaotong University, Chongqing South Road 280, Shanghai 200025, China

3. State Key Laboratory of Precision Spectroscopy, East China Normal University, Dongchuan Road 500, Shanghai 200241, China

4. Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Cailun Road 1200, Shanghai 201203, China

5. State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Meilong Road 130, Shanghai 200237, China

Abstract

A general design strategy for photo-triggered release of acyl radicals was developed. With an acetyl radical donor, we showed the potential of acyl radicals to precisely modulate cell redox homeostasis, to promote NSC differentiation, and to improve the cognitive abilities of early AD mice.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

East China Normal University

Shanghai Municipal Education Commission

Innovative Research Team of High-level Local University in Shanghai

Science and Technology Commission of Shanghai Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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