First ligand-free, microwave-assisted, Heck cross-coupling reaction in pure water on a nucleoside – application to the synthesis of antiviral BVDU
Author:
Affiliation:
1. Transformations Intégrées de la Matière Renouvelable
2. UTC-ESCOM
3. Centre de Recherche de Royallieu
4. F-60200 Compiègne, France
5. Department of Chemistry
Abstract
For the first time, a palladium catalyzed Heck cross-coupling reaction between 5-iodo-2′-deoxyuridine and various acrylate derivatives was performed using ligand-free conditions and microwave assistance in pure water.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2014/RA/C4RA09798J
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