Efficient asymmetric synthesis of chiral alcohols using high 2-propanol tolerance alcohol dehydrogenase SmADH2 via an environmentally friendly TBCR system-Reference-Cited by-同舟云学术

Efficient asymmetric synthesis of chiral alcohols using high 2-propanol tolerance alcohol dehydrogenase SmADH2 via an environmentally friendly TBCR system

Published:2020 Issue:1 Volume:10 Page:70-78
ISSN:2044-4753
Container-title:Catalysis Science & Technology
language:en
Short-container-title:Catal. Sci. Technol.

Author:

Yang Zeyu¹²³⁴⁵^ORCID,Fu Hengwei¹²³⁴⁵,Ye Wenjie¹²³⁴⁵,Xie Youyu¹²³⁴⁵,Liu Qinghai¹²³⁴⁵,Wang Hualei¹²³⁴⁵^ORCID,Wei Dongzhi¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Bioreactor Engineering

2. New World Institute of Biotechnology

3. East China University of Science and Technology

4. Shanghai 200237

5. PR China

Abstract

Based on substrate-coupled cofactor regeneration system, a high 2-propanol tolerance SmADH2 together with TBCR system can synthesise structurally diverse chiral alcohols at a high substrate loading with only 1.25 equivalents of 2-propanol.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CY/C9CY01794A

Reference34 articles.

1. A green-by-design biocatalytic process for atorvastatin intermediate

2. A practical and diastereoselective synthesis of angiotensin converting enzyme inhibitors.