Near-infrared emitting dual-stimuli-responsive carbon dots from endogenous bile pigments

Author:

Fathi Parinaz12ORCID,Moitra Parikshit3,McDonald Madeleine M.12,Esch Mandy B.4ORCID,Pan Dipanjan1256ORCID

Affiliation:

1. Departments of Bioengineering, Materials Science and Engineering, and Beckman Institute, University of Illinois, 61801, USA

2. Mills Breast Cancer Institute, Carle Foundation Hospital, Urbana, Illinois 61801, USA

3. Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA

4. Biomedical Technologies Group, Microsystems and Nanotechnology Division, Physical Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA

5. Departments of Diagnostic Radiology and Nuclear Medicine and Pediatrics, University of Maryland Baltimore, Health Sciences Facility III, 670 W Baltimore St., Baltimore, Maryland, 21201, USA

6. Department of Chemical, Biochemical and Environmental Engineering, University of Maryland Baltimore County, Interdisciplinary Health Sciences Facility, 1000 Hilltop Circle, Baltimore, Maryland, 21250, USA

Abstract

Using biliverdin or bilirubin as carbon dot precursors results in synthesis of enzyme-responsive and pH-responsive carbon dots. BR-CDots can additionally be used for imaging in the NIR window.

Funder

National Institute of Biomedical Imaging and Bioengineering

National Institutes of Health

U.S. Department of Defense

University of Illinois

National Physical Science Consortium

National Institute of Standards and Technology

Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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