Glucose oxidase mediated targeted cancer-starving therapy by biotinylated self-assembled vesicles-Reference-Cited by-同舟云学术

Glucose oxidase mediated targeted cancer-starving therapy by biotinylated self-assembled vesicles

Published:2018 Issue:71 Volume:54 Page:9929-9932
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Dinda Soumik¹²³⁴,Sarkar Saheli¹²³⁴,Das Prasanta Kumar¹²³⁴^ORCID

Affiliation:

1. Department of Biological Chemistry

2. Indian Association for the Cultivation of Science

3. Kolkata – 700 032

4. India

Abstract

Glucose oxidase (GOx) mediated targeted cancer-starving therapy, by blocking the energy supply to cancer cells, has been demonstrated using GOx encapsulating monolayer vesicles of a trimesic acid based biotinylated amphiphile (TMB). GOx, loaded within the TMB vesicles, was selectively delivered inside the cancer cells, resulting in ∼6-fold higher killing of cancer cells compared to normal cells.

Funder

Science and Engineering Research Board

Department of Science and Technology, Ministry of Science and Technology

Council of Scientific and Industrial Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C8CC03599G

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