Diastereoselective synthesis and profiling of bicyclic imidazolidinone derivatives bearing a difluoromethylated catechol unit as potent phosphodiesterase 4 inhibitors-Reference-Cited by-同舟云学术

Diastereoselective synthesis and profiling of bicyclic imidazolidinone derivatives bearing a difluoromethylated catechol unit as potent phosphodiesterase 4 inhibitors

Published:2018 Issue:38 Volume:16 Page:6900-6908
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Dorokhov Valentin S.¹²³⁴⁵^ORCID,Golovanov Ivan S.¹²³^ORCID,Tartakovsky Vladimir A.¹²³,Sukhorukov Alexey Yu.¹²³^ORCID,Ioffe Sema L.¹²³^ORCID

Affiliation:

1. N. D. Zelinsky Institute of Organic Chemistry

2. Moscow

3. Russian Federation

4. Higher Chemical College of the Russian Academy of Sciences

5. D. Mendeleev University of Chemical Technology of Russia

Abstract

Metal-mediated C–H functionalization of cyclic N-oxides was exploited to access new highly potent analogs of the phosphodiesterase 4 inhibitor Ro-20-1724.

Funder

Russian Foundation for Basic Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB01039K

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1. Phosphodiesterase-4 inhibitors: a review of current developments (2010 – 2012)

2. Inhibitors of phosphodiesterase 4 (PDE 4): A new therapeutic option in the treatment of psoriasis vulgaris and psoriatic arthritis

3. PDE4: A Novel Target in the Treatment of Chronic Obstructive Pulmonary Disease