Targeting immune checkpoint B7-H3 antibody–chlorin e6 bioconjugates for spectroscopic photoacoustic imaging and photodynamic therapy

Author:

Zhu Lipeng12345,Liu Jie12345,Zhou Guangyu12345,Ng Hoi Man6758,Ang Irene L.12345,Ma Guofang910118,Liu Yubin12345,Yang Shuo12345,Zhang Fengjuan12345,Miao Kai12345,Poon Terence C. W.12345,Zhang Xuanjun12345ORCID,Yuan Zhen12345ORCID,Deng Chu-Xia12345,Zhao Qi12345ORCID

Affiliation:

1. Cancer Centre

2. Institute of Translational Medicine

3. Faculty of Health Sciences

4. University of Macau

5. Macau

6. Clinical Laboratory

7. Kiang Wu Hospital

8. China

9. Geriatric Department

10. China–Japan Union Hospital of Jilin University

11. Changchun

Abstract

In this study, we constructed bioconjugates of targeting immune checkpoint B7-H3 antibody and chlorin e6 to treat non-small cell lung cancer under the guidance of spectroscopic photoacoustic and fluorescence imaging.

Funder

Fundo para o Desenvolvimento das Ciências e da Tecnologia

Universidade de Macau

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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