C5-Morpholinomethylation of N1-sulfonylcytosines by a one-pot microwave assisted Mannich reaction-Reference-Cited by-同舟云学术

C5-Morpholinomethylation of N1-sulfonylcytosines by a one-pot microwave assisted Mannich reaction

Published:2018 Issue:15 Volume:16 Page:2678-2687
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Matić Josipa¹²³⁴⁵^ORCID,Nekola Irena⁶⁴⁵^ORCID,Višnjevac Aleksandar⁷⁸³⁹⁴^ORCID,Kobetić Renata¹²³⁴⁵^ORCID,Martin-Kleiner Irena¹⁰¹¹³⁴⁵,Kralj Marijeta¹⁰¹¹³⁴⁵^ORCID,Žinić Biserka¹²³⁴⁵^ORCID

Affiliation:

1. Laboratory for Biomolecular Interactions and Spectroscopy

2. Division of Organic Chemistry and Biochemistry

3. Ruđer Bošković Institute

4. 10000 Zagreb

5. Croatia

6. Pliva Croatia TAPI R&D

7. Laboratory for Chemical and Biological Crystallography

8. Division of Physical Chemistry

9. Bijenička cesta 54

10. Laboratory of Experimental Therapy

11. Division of Molecular Medicine

Abstract

A fast and efficient route for the introduction of a morpholinomethyl moiety in the C5 position of the sulfonylated cytosine nucleobase has been developed.

Funder

Hrvatska Zaklada za Znanost

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB00253C

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