Antibacterial low molecular weight cationic polymers: dissecting the contribution of hydrophobicity, chain length and charge to activity

Author:

Grace James L.123,Huang Johnny X.4567,Cheah Soon-Ee823,Truong Nghia P.123ORCID,Cooper Matthew A.4567,Li Jian823,Davis Thomas P.123910,Quinn John F.123,Velkov Tony823,Whittaker Michael R.123

Affiliation:

1. Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology

2. Parkville

3. Australia

4. Institute of Molecular Biosciences

5. The University of Queensland

6. Brisbane

7. Australia 4072

8. Monash Institute of Pharmaceutical Sciences

9. Department of Chemistry

10. Warwick University

Abstract

We report the antibacterial activity of a novel class of low molecular weight cationic polymers synthesised using Cu(0) mediated polymerisation.

Funder

Australian Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference51 articles.

1. CDC-Get Smart: Know When Antibiotics Work 2013, 17 April 2014, available from: http://www.cdc.gov/getsmart/antibiotic-use/antibiotic-resistance-faqs.html#how-bacteria-resist

2. Antimicrobial Resistance in the 21st Century: A Multifaceted Challenge

3. Challenges in Identifying New Antimicrobial Agents Effective for Treating Infections with Acinetobacter baumannii and Pseudomonas aeruginosa

4. WHO , ANTIMICROBIAL RESISTANCE Global Report on Surveillance, WHO Library, 2014

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