A proof-reading mechanism for non-proteinogenic amino acid incorporation into glycopeptide antibiotics
Author:
Affiliation:
1. The Monash Biomedicine Discovery Institute
2. Department of Biochemistry and Molecular Biology
3. Monash University
4. Clayton
5. Australia
Abstract
A complex interplay of non-ribosomal peptide synthetase domains works together with trans-acting enzymes to ensure effective GPA biosynthesis.
Funder
National Health and Medical Research Council
Australian Research Council
Monash University
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC03678D
Reference64 articles.
1. Nonribosomal Peptide Synthesis-Principles and Prospects
2. Nonproteinogenic Amino Acid Building Blocks for Nonribosomal Peptide and Hybrid Polyketide Scaffolds
3. The many faces and important roles of protein–protein interactions during non-ribosomal peptide synthesis
4. Aminoacyl-CoAs as Probes of Condensation Domain Selectivity in Nonribosomal Peptide Synthesis
5. Adenylation Domains in Nonribosomal Peptide Engineering
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