Discovery of a low affinity thyrotropin-releasing hormone (TRH)-like peptide that exhibits potent inhibition of scopolamine-induced memory impairment in mice-Reference-Cited by-同舟云学术

Discovery of a low affinity thyrotropin-releasing hormone (TRH)-like peptide that exhibits potent inhibition of scopolamine-induced memory impairment in mice

Published:2015 Issue:70 Volume:5 Page:56872-56884
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Meena Chhuttan L.¹²³,Ingole Shubdha⁴²³,Rajpoot Satyendra⁴²³,Thakur Avinash⁴²³,Nandekar Prajwal P.⁵²³,Sangamwar Abhay T.⁵²³,Sharma Shyam S.⁴²³,Jain Rahul¹²³

Affiliation:

1. Department of Medicinal Chemistry

2. National Institute of Pharmaceutical Education and Research

3. India

4. Department of Pharmacology and Toxicology

5. Department of Pharmacoinformatics

Abstract

TRH-like peptides were synthesized in which the critical N-terminus residuel-pGlu was replaced with various heteroaromatic rings, and the central residue histidine with 1-alkyl-l-histidines.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA06935A

Reference54 articles.

1. The identity of chemical and hormonal properties of the thyrotropin releasing hormone and pyroglutamyl-histidyl-proline amide

2. Characterization of Ovine Hypothalamic Hypophysiotropic TSH-releasing Factor

3. Mechanism of Thyrotropin Releasing Hormone Stimulation of Pituitary Hormone Secretion

4. Identification of a Preassembled TRH Receptor-Gq/11 Protein Complex in HEK293 Cells

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