Negative hyperconjugation effect on the reactivity of phosphoramide mustard derivatives as a DNA alkylating agent: theoretical and experimental insights-Reference-Cited by-同舟云学术

Negative hyperconjugation effect on the reactivity of phosphoramide mustard derivatives as a DNA alkylating agent: theoretical and experimental insights

Published:2017 Issue:19 Volume:41 Page:11036-11052
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Bonsaii Mahyar¹²³⁴⁵^ORCID,Gholivand Khodayar¹⁶⁴⁵^ORCID,Khosravi Morteza¹²³⁴⁵,Abdi Khosrou⁷⁸⁴⁵

Affiliation:

1. Department of Chemistry

2. Islamic Azad University

3. North Tehran Branch

4. Tehran

5. Iran

6. Tarbiat Modares University

7. Department of Medicinal Chemistry and Radiopharmacy

8. Tehran University of Medical Sciences

Abstract

In this work we suggest new factors affecting the reactivity of compounds similar to cyclophosphamide; as their reactivity mainly relies on the frontier molecular orbitals, the factors causing changes in the frontier molecular orbitals, alter the reactivity of these compounds too.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/NJ/C7NJ01402C

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