Shielding against breast tumor relapse with an autologous chemo-photo-immune active Nano–Micro-Sera based fibrin implant

Author:

Mimansa 1,Zafar Mohammad Adeel2,Verma Dinesh Kumar3,Das Reena4,Agrewala Javed Naim2ORCID,Shanavas Asifkhan1ORCID

Affiliation:

1. Inorganic & Organic Nanomedicine (ION) Lab, Chemical Biology Unit, Institute of Nano Science and Technology, Sector-81, Knowledge City, Sahibzada Ajit Singh Nagar, Punjab 140306, India

2. Department of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab 140001, India

3. All India Institute of Medical Sciences Bilaspur, Changar Palasiyan, Noa, Himachal Pradesh, 174001, India

4. Department of Haematology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India

Abstract

An ‘all-in-one’ autologous intraoperative implant is demonstrated to deliver localized chemo-photothermal immunotherapy with significant inhibition of residual cancer cells and improved survival in preclinical triple negative breast tumor model.

Funder

University Grants Commission

Department of Biotechnology, Ministry of Science and Technology

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

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