An efficient synthesis of 1-arylindazole-3-carboxamides using nitrile imines, isocyanides and 2-hydroxymethylbenzoic acid, followed by a chemoselective Buchwald–Hartwig intramolecular cyclization-Reference-Cited by-同舟云学术

An efficient synthesis of 1-arylindazole-3-carboxamides using nitrile imines, isocyanides and 2-hydroxymethylbenzoic acid, followed by a chemoselective Buchwald–Hartwig intramolecular cyclization

Published:2016 Issue:41 Volume:6 Page:34913-34920
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Giustiniano M.¹²³⁴,Mercalli V.⁵⁶⁷⁴,Novellino E.¹²³⁴,Tron G. C.⁵⁶⁷⁴

Affiliation:

1. Dipartimento di Farmacia

2. Università degli Studi di Napoli “Federico II”

3. 80131 Napoli

4. Italy

5. Dipartimento di Scienze del Farmaco

6. Università degli Studi del Piemonte Orientale “A. Avogadro”

7. 28100 Novara

Abstract

A convergent, efficient and regio-selective two-step synthesis of pharmaceutically relevant 1-arylindazole-3-carboxamides through an isocyanide-based reaction and a Buchwald–Hartwig cyclization.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA01442A

Reference25 articles.

1. Synthesis of indazole motifs and their medicinal importance: An overview

2. Pharmacological Properties of Indazole Derivatives: Recent Developments

3. Synthesis of Substituted 1H-Indazoles from Arynes and Hydrazones

4. New Synthesis of 1-Substituted-1H-indazoles via 1,3-Dipolar Cycloaddition of in situ Generated Nitrile Imines and Benzyne

5. Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase

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