Twisted amide electrophiles enable cyclic peptide sequencing
Author:
Affiliation:
1. Davenport Research Laboratories
2. Department of Chemistry
3. University of Toronto
4. Toronto
5. Canada
6. Lunenfeld-Tanenbaum Research Institute
7. Mount Sinai Hospital
Abstract
Preserving the electrophilic carbonyl group of an aziridine amide in a macrocycle enables cyclic peptide sequencing by chemoselective linearization and tandem mass spectrometry.
Funder
Natural Sciences and Engineering Research Council of Canada
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB01050K
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1. Macrocycles: lessons from the distant past, recent developments, and future directions
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