Macrophage-targeting and reactive oxygen species (ROS)-responsive nanopolyplexes mediate anti-inflammatory siRNA delivery against acute liver failure (ALF)-Reference-Cited by-同舟云学术

Macrophage-targeting and reactive oxygen species (ROS)-responsive nanopolyplexes mediate anti-inflammatory siRNA delivery against acute liver failure (ALF)

Published:2018 Issue:7 Volume:6 Page:1986-1993
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Zhang Wenxin¹²³⁴⁵,Zhou Yang¹²³⁴⁵,Li Xudong¹²³⁴⁵,Xu Xin¹²³⁴⁵,Chen Yongbing⁶⁷⁸⁹,Zhu Rongying⁶⁷⁸⁹,Yin Lichen¹²³⁴⁵^ORCID

Affiliation:

1. Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices

2. Institute of Functional Nano and Soft Materials (FUNSOM)

3. Collaborative Innovation Center of Suzhou Nano Science and Technology

4. Soochow University

5. Suzhou 215123

6. Department of Thoracic Surgery

7. the Second Affiliated Hospital of Soochow University

8. Suzhou 215004

9. P.R. China

Abstract

Macrophage-targeting and ROS-degradable nanopolyplexes were developed to realize efficient TNF-α siRNA delivery toward the treatment of acute liver failure.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

Natural Science Foundation of Jiangsu Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2018/BM/C8BM00389K

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1. Drug-Related Hepatotoxicity