Surface-decorated nanoparticles clicked into nanoparticle clusters for oligonucleotide encapsulation
Author:
Affiliation:
1. Department of Biomedical Materials Engineering
2. Kangwon National University
3. Chuncheon
4. Republic of Korea
5. Chuncheon Center
6. Korea Basic Science Institute
7. Institute of Molecular Science and Fusion Technology
Abstract
AuNPs with bPEI and azide modification are loaded with CpG and self-assembled to AuNCs by click chemistry using an alkyne-terminated MMP-2 cleavable peptide as a linker. The clusters are dissembled by MMP-2 to release CpG in a stimuli-responsive manner.
Funder
Ministry of Science and ICT, South Korea
Ministry of Education
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA06622B
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