Fine-tuning of stable organic free-radical photosensitizers for photodynamic immunotherapy-Reference-Cited by-同舟云学术

Fine-tuning of stable organic free-radical photosensitizers for photodynamic immunotherapy

Published:2024 Issue:17 Volume:15 Page:6421-6431
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wang Xiang¹,Shi Gaona¹,Wei Rao¹,Li Meng²^ORCID,Zhang Qingyang¹^ORCID,Zhang Tiantai¹,Chen Chuan-Feng²^ORCID,Hu Hai-Yu¹^ORCID

Affiliation:

1. State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100050, China

2. Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

Abstract

We developed a novel strategy to enhance type I photodynamic therapy by using doublet radicals instead of radical intermediates, which effectively generated ROS, triggered anti-tumor immune response and superior photodynamic immunotherapy efficacy.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Chinese Academy of Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D3SC06826A

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