Nickel-catalyzed regio- and enantio-selective Markovnikov hydromonofluoroalkylation of 1,3-dienes-Reference-Cited by-同舟云学术

Nickel-catalyzed regio- and enantio-selective Markovnikov hydromonofluoroalkylation of 1,3-dienes

Published:2022 Issue:42 Volume:13 Page:12519-12526
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Liao Ling¹,Zhang Ying¹,Wu Zhong-Wei¹,Ye Zhong-Tian¹,Zhang Xue-Xin¹,Chen Guangying²,Yu Jin-Sheng¹²^ORCID

Affiliation:

1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, East China Normal University, Shanghai 200062, China

2. Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China

Abstract

We report a highly enantio- and regio-selective Markovnikov hydromonofluoro(methyl)alkylation of 1,3-dienes using chiral Ni catalysis, allowing access to chiral allylic compounds bearing a CH2F, CD2F or monofluoroalkyl group at the stereocenter.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Fundamental Research Funds for the Central Universities

East China Normal University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC03958C

Reference114 articles.