Conformational fingerprinting of tau variants and strains by Raman spectroscopy

Author:

Devitt George12345ORCID,Crisford Anna12345,Rice William67345,Weismiller Hilary A.891011,Fan Zhanyun1213141516,Commins Caitlin1213141516,Hyman Bradley T.1213141516ORCID,Margittai Martin891011ORCID,Mahajan Sumeet67345ORCID,Mudher Amrit12345ORCID

Affiliation:

1. School of Biological Sciences

2. Faculty of Environmental and Life Sciences

3. University of Southampton

4. Southampton SO17 1BJ

5. UK

6. School of Chemistry

7. Faculty of Engineering and Physical Sciences

8. Department of Chemistry and Biochemistry

9. University of Denver

10. Denver

11. USA

12. Department of Neurology

13. Harvard Medical School

14. MassGeneral Institute for Neurodegenerative Disease

15. Massachusetts General Hospital

16. Charlestown

Abstract

We report that the physiochemical properties of the aggregation environment dictate the conformation of tau strains, which can be characterized and distinguished using Raman spectroscopy.

Funder

H2020 European Research Council

Engineering and Physical Sciences Research Council

National Institutes of Health

Rosetrees Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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