Grignard-mediated rearrangement of trifluoroacetyl from dihydroisoquinoline enamides to afford tertiary trifluoromethylcarbinols
Author:
Affiliation:
1. Bio & Drug Discovery Division
2. Korea Research Institute of Chemical Technology
3. Daejeon 34114
4. Korea
5. Department of Medicinal Chemistry and Pharmacology
6. Department of Chemistry
Abstract
A novel approach for the addition of tertiary trifluoromethylcarbinols at the β-position of cyclic enamides has been developed.
Funder
Korea Research Institute of Chemical Technology
National Research Foundation of Korea
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/OB/C7OB03079G
Reference36 articles.
1. Asymmetric Synthesis of Isoquinoline Alkaloids: 2004–2015
2. Chemistry and Biology of the Tetrahydroisoquinoline Antitumor Antibiotics
3. Transition Metal-Catalyzed Enantioselective Hydrogenation of Enamines and Imines
4. Total Syntheses of Aporphine Alkaloids via Benzyne Chemistry: An Approach to the Formation of Aporphine Cores
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