pH-Responsive doxorubicin-loaded magnetosomes for magnetic resonance-guided focused ultrasound real-time monitoring and ablation of breast cancer

Author:

Tang Na12,Zhu Yi2,Lu Ziwei3,Deng Jiali42,Guo Jiajing2,Ding Xinyi2,Wang Jingyi42,Cao Rong2,Chen An2,Huang Zhongyi5,Lu Hongwei6,Wang Zhongling2ORCID

Affiliation:

1. Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China

2. Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China

3. Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China

4. School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China

5. Department of Neurology, School of Medicine, New York University, New York, 10016, USA

6. Department of Biomedical Engineering, College of Engineering, Shantou University, Shantou, 515063, China

Abstract

We have successfully prepared pH-responsive doxorubicin-loaded magnetosomes as an integrated diagnostic and theranostic nanoplatform that is responsive to an acidic microenvironment and can be a synergistic sensitizer for MRgFUS ablation therapy.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Shanghai Key Laboratory of Molecular Imaging

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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