Sequential administration of virus-like particle-based nanomedicine to elicit enhanced tumor chemotherapy

Author:

Wang Chufan1,Xiao Cheng1,Chen Yurong2,Li Yao1ORCID,Zhang Qiang1,Shan Wenjun3ORCID,Li Yulin4,Bi Shengli5,Wang Yunlong4,Wang Xiumin2,Ren Lei16ORCID

Affiliation:

1. Key Laboratory of Biomedical Engineering of Fujian Province University/Research Center of Biomedical Engineering of Xiamen, Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, P. R. China

2. School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, P. R. China

3. Department of Pharmacology, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing 400038, P. R. China

4. Henan Bioengineering Research Center, Zhengdong New District, Zhengzhou, China

5. Chinese Center for Disease Control & Prevention, Institute Viral Disease Control & Prevention, Beijing, P. R. China

6. State Key Lab of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen 361005, P. R. China

Abstract

Immunological problems have prevented applications of Virus like particles (VLPs). Here, we show that using immune-orthogonal VLPs sequentially and modifying of major immune region can circumvent immune responses after repeated administration.

Funder

National Natural Science Foundation of China

Fujian Provincial Department of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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