Taming the dynamics in a pharmaceutical by cocrystallization: investigating the impact of the coformer by solid-state NMR-Reference-Cited by-同舟云学术

Taming the dynamics in a pharmaceutical by cocrystallization: investigating the impact of the coformer by solid-state NMR

Published:2021 Issue:39 Volume:23 Page:6859-6870
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Szell Patrick M. J.¹^ORCID,Lewandowski Józef R.²^ORCID,Blade Helen³^ORCID,Hughes Leslie P.³^ORCID,Nilsson Lill Sten O.⁴^ORCID,Brown Steven P.¹^ORCID

Affiliation:

1. Department of Physics, University of Warwick, Coventry, CV4 7AL, UK

2. Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK

3. Oral Product Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield, UK

4. Early Product Development and Manufacturing, Pharmaceutical Sciences, R&D, AstraZeneca, Gothenburg, Sweden

Abstract

The anti-HIV pharmaceutical efavirenz is highly dynamic in its crystalline state, and we show that these dynamics can be tamed through the introduction of a coformer.

Funder

AstraZeneca

Innovate UK

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CE/D1CE01084K

Reference83 articles.

1. Pharmaceutical cocrystals, salts and multicomponent systems; intermolecular interactions and property based design

2. Crystal Engineering: From Molecule to Crystal

3. Electron diffraction determines molecular absolute configuration in a pharmaceutical nanocrystal

4. Crystal engineering of the composition of pharmaceutical phases. Do pharmaceutical co-crystals represent a new path to improved medicines?

5. Pharmaceutical cocrystals: along the path to improved medicines

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