Hydrogel-mediated tumor T cell infiltration and immune evasion to reinforce cancer immunotherapy-Reference-Cited by-同舟云学术

Hydrogel-mediated tumor T cell infiltration and immune evasion to reinforce cancer immunotherapy

Published:2024 Issue:2 Volume:9 Page:295-304
ISSN:2055-6756
Container-title:Nanoscale Horizons
language:en
Short-container-title:Nanoscale Horiz.

Author:

Xu Guixiang¹,Liu Kai²,Chen Xiangwu¹,Lin Yang¹,Yu Cancan¹,Nie Xinxin¹,He Wenxiu¹,Karin Nathan³,Luan Yuxia¹^ORCID

Affiliation:

1. Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China

2. Department of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, China

3. Department of Immunology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, 32000, Israel

Abstract

An injectable hydrogel was designed to reinforce cancer immunotherapy by regulating CXCL10 degradation to amplify tumor T cell infiltration and inactivating PD-L1 to eliminate the PD-L1-governed immune evasion.

Funder

Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

Israel Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NH/D3NH00401E

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