Oral delivery of curcumin via porous polymeric nanoparticles for effective ulcerative colitis therapy

Author:

Chen Qiubing12345,Si Xiaoying12345,Ma Lijun12345,Ma Panpan12345,Hou Meili12345,Bai Shuang12345,Wu Xiaoshuai12345,Wan Ying675,Xiao Bo12345ORCID,Merlin Didier89101112

Affiliation:

1. Institute for Clean Energy and Advanced Materials

2. Faculty of Materials and Energy

3. Southwest University

4. Chongqing

5. P. R. China

6. College of Life Science and Technology, Huazhong University of Science and Technology

7. Wuhan 430074

8. Center for Diagnostics and Therapeutics

9. Institute for Biomedical Science

10. Georgia State University

11. Atlanta

12. USA

Abstract

Curcumin (CUR) has been encapsulated into porous polymeric nanoparticles (NPs), and the resultant CUR-loaded porous polymeric NPs exhibited superior therapeutic efficacy in alleviating ulcerative colitis, in comparison with CUR-loaded non-porous polymeric NPs.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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