Design, synthesis, and biological evaluation of novel thieno[3,2-<i>d</i>]pyrimidine derivatives as potent antitumor agents-Reference-Cited by-同舟云学术

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Design, synthesis, and biological evaluation of novel thieno[3,2-d]pyrimidine derivatives as potent antitumor agents

Published:2023 Issue:46 Volume:47 Page:21318-21331
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Zhang Yadong¹^ORCID,Shen Jiwei¹²³,Li JiaWei¹,Wang Zhi¹,Wang Yue¹,Zhu Yan¹,Ding Shi¹²³,Zhou YunPeng¹²³,Chen Ye¹²³,Liu Ju¹²³

Affiliation:

1. College of Pharmacy of Liaoning University, Shenyang, Liaoning 110036, P. R. China

2. API Engineering Technology Research Center of Liaoning Province, Shenyang, Liaoning 110036, P. R. China

3. Small Molecular Targeted Drug R&D Engineering Research Center of Liaoning Province, Shenyang, Liaoning 110036, P. R. China

Abstract

Two series of substituted thieno[3,2-d]pyrimidine derivatives as EZH2 inhibitors were synthesized via structural modifications of tazemetostat.

Funder

Natural Science Foundation of Liaoning Province

Department of Education of Liaoning Province

Department of Science and Technology of Liaoning Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NJ/D3NJ03576J

Reference33 articles.

1. Hallmarks of Cancer: The Next Generation

2. EZH2: a novel target for cancer treatment

3. PRC2 directly methylates GATA4 and represses its transcriptional activity

4. Polycomb Group Protein Ezh2 Controls Actin Polymerization and Cell Signaling

5. Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells

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1. One‐Pot Three‐Component Construction of 2,4‐Diarylbenzo[4,5] thieno[3,2‐d] pyrimidines Using Elemental Sulfur as a Sulfur Source;ChemistrySelect;2024-06-18

2. Amorphous-nanocrystalline dual-phase structured Fe78Si13B9 alloy ribbons and their efficiency for degradation of direct yellow dye;Reaction Kinetics, Mechanisms and Catalysis;2024-02-07

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