Interactions between heme and tau-derived R1 peptides: binding and oxidative reactivity

Abstract

The first octadecapeptide repeat fragment of tau, R1τ, in both N-terminal amine free and acetylated forms, binds with moderate affinity to both monomeric and dimeric hemin forming 1 : 1 complexes, but does not form a 2 : 1 complex. The peroxidase activity of hemin-R1τ complexes and the effect of hemin on the aggregation properties of R1τ have been also studied.