Chiral phosphoric acid-catalyzed enantioselective synthesis of functionalized pyrrolinones containing a geminal diamine core <i>via</i> an aza-Friedel–Crafts reaction of newly developed pyrrolinone ketimines-Reference-Cited by-同舟云学术

Chiral phosphoric acid-catalyzed enantioselective synthesis of functionalized pyrrolinones containing a geminal diamine core via an aza-Friedel–Crafts reaction of newly developed pyrrolinone ketimines

Published:2024 Issue:5 Volume:11 Page:1437-1443
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Zhang Tong¹,Wang Zhen-Hua¹^ORCID,Li Yong²,Zhao Jian-Qiang¹^ORCID,You Yong¹^ORCID,Zhang Yan-Ping¹,Yin Jun-Qing¹,Yuan Wei-Cheng¹^ORCID

Affiliation:

1. Innovation Research Center of Chiral Drugs, Institute for Advanced Study, Chengdu University, Chengdu 610106, China

2. College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, IATTI, Chongqing University of Arts and Sciences, Chongqing 402160, China

Abstract

A class of novel pyrrolinone ketimines was synthesized for the first time and applied to the asymmetric aza-Friedel–Crafts reaction with phenolic compounds.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D3QO01909H

Reference54 articles.

1. Indolylvinyl Ketones: Building Blocks for the Synthesis of Natural Products and Bioactive Compounds

2. Counting on natural products for drug design

3. Biology-Oriented Synthesis

4. Asymmetric Propargylic C−C Bond Formation Using Metal–Allenylidene Species

5. Scaffold Architecture and Pharmacophoric Properties of Natural Products and Trade Drugs: Application in the Design of Natural Product-Based Combinatorial Libraries

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