Biscarbene gold(i) complexes: structure–activity-relationships regarding antibacterial effects, cytotoxicity, TrxR inhibition and cellular bioavailability-Reference-Cited by-同舟云学术

Biscarbene gold(i) complexes: structure–activity-relationships regarding antibacterial effects, cytotoxicity, TrxR inhibition and cellular bioavailability

Published:2017 Issue:8 Volume:8 Page:1681-1689
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Schmidt Claudia¹²³⁴^ORCID,Karge Bianka⁵⁶⁷⁴,Misgeld Rainer⁸⁹¹⁰⁴,Prokop Aram⁸⁹¹⁰⁴,Brönstrup Mark⁵⁶⁷⁴^ORCID,Ott Ingo¹²³⁴^ORCID

Affiliation:

1. Institute of Medicinal and Pharmaceutical Chemistry

2. Technische Universität Braunschweig

3. 38106 Braunschweig

4. Germany

5. Department of Chemical Biology

6. Helmholtz Centre for Infection Research and German Centre for Infection Research (DZIF)

7. 38124 Braunschweig

8. Department of Pediatric Oncology

9. Children's Hospital Cologne

10. 50735 Cologne

Abstract

Biscarbene gold(i) complexes were prepared and evaluated for their effects against cancer cells and pathogenic bacteria.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C7MD00269F

Reference43 articles.

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5. Update on metal N-heterocyclic carbene complexes as potential anti-tumor metallodrugs

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