Alkyne–azide cycloaddition analogues of dehydrozingerone as potential anti-prostate cancer inhibitors via the PI3K/Akt/NF-kB pathway-Reference-Cited by-同舟云学术

Alkyne–azide cycloaddition analogues of dehydrozingerone as potential anti-prostate cancer inhibitors via the PI3K/Akt/NF-kB pathway

Published:2017 Issue:11 Volume:8 Page:2115-2124
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Kumar Chetan¹²,Rasool Reyaz Ur³⁴²⁵⁶,Iqra Zainab⁵⁶⁷²,Nalli Yedukondalu¹²^ORCID,Dutt Prabhu¹²,Satti Naresh K.¹²,Sharma Neha¹²,Gandhi Sumit G.⁸⁶⁹²,Goswami Anindya⁵⁶⁷²,Ali Asif¹²^ORCID

Affiliation:

1. Natural Product Chemistry Division

2. India

3. Academy of Scientific & Innovative Research (AcSIR)

4. New Delhi-110001

5. Cancer Pharmacology Division

6. CSIR-Indian Institute of Integrative Medicine

7. Jammu-180001

8. Plant Biotechnology division

9. Jammu

Abstract

Alkyne–azide cycloaddition derivatives of DHZ (1) were synthesized and screened for cytotoxic potential in which the derivatives, 3, 6, 7, 8, 9 and 15 displayed most potent with IC₅₀ value ranging from 1.8–3.0 μM.

Funder

Ministry of Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C7MD00267J

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