A general approach to the design of allosteric, transcription factor-regulated DNAzymes

Author:

Adornetto G.123,Porchetta A.12345,Palleschi G.12345,Plaxco K. W.678910,Ricci F.12345

Affiliation:

1. Dipartimento di Scienze e Tecnologie Chimiche University of Rome Tor Vergata

2. Rome 00133

3. Italy

4. Consorzio Interuniversitario Biostrutture e Biosistemi “INBB”

5. Rome 00136

6. Department of Chemistry and Biochemistry

7. University of California Santa Barbara

8. Santa Barbara

9. USA

10. Center for Bioengineering

Abstract

Here we explore a general strategy for the rational design of nucleic acid catalysts that can be allosterically activated by specific nucleic-acid binding proteins.

Funder

European Research Council

Research Executive Agency

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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