Discovery of pyrano[2,3-d]pyrimidine-2,4-dione derivatives as novel PARP-1 inhibitors: design, synthesis and antitumor activity-Reference-Cited by-同舟云学术

Discovery of pyrano[2,3-d]pyrimidine-2,4-dione derivatives as novel PARP-1 inhibitors: design, synthesis and antitumor activity

Published:2021 Issue:8 Volume:11 Page:4454-4464
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Abd El-sattar Nour E. A.¹²³⁴⁵^ORCID,Badawy Eman H. K.¹²³⁴⁵,Elrazaz Eman Z.⁶⁷⁵⁸⁹^ORCID,Ismail Nasser S. M.¹⁰¹¹¹²¹³⁹

Affiliation:

1. Department of Chemistry

2. Organic Labs

3. Computational Chemistry Lab

4. Faculty of Science

5. Ain Shams University

6. Department of Pharmaceutical Chemistry

7. Faculty of Pharmacy

8. 11566 Cairo

9. Egypt

10. Pharmaceutical Chemistry Department

11. Faculty of Pharmaceutical Sciences and Pharmaceutical Industries

12. Future University in Egypt (FUE)

13. Cairo 12311

Abstract

PARP-1 are involved in DNA repair damage and so PARP-1 inhibitors have been used as potentiators in combination with DNA damaging cytotoxic agents to compromise the cancer cell DNA repair mechanism, resulting in genomic dysfunction and cell death.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D0RA10321G

Reference27 articles.

1. PARP inhibition: PARP1 and beyond

2. The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases

3. DNA single-strand break repair

4. Trapping Poly(ADP-Ribose) Polymerase

5. Niraparib: A Poly(ADP-ribose) Polymerase (PARP) Inhibitor for the Treatment of Tumors with Defective Homologous Recombination

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