Highly-fluorescent BODIPY-functionalised metallacages as drug delivery systems: synthesis, characterisation and cellular accumulation studies

Author:

Aikman Brech1ORCID,Bonsignore Riccardo12ORCID,Woods Ben3,Doellerer Daniel4ORCID,Scotti Riccardo1,Schmidt Claudia1ORCID,Heidecker Alexandra A.5,Pöthig Alexander5ORCID,Sayers Edward J.6ORCID,Jones Arwyn T.6ORCID,Casini Angela17ORCID

Affiliation:

1. Chair of Medicinal and Bioinorganic Chemistry, Department of Chemistry, Technical University of Munich, Lichtenbergstr. 4, 85748 Garching b. München, Germany

2. Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche, Università degli Studi di Palermo, Viale delle Scienze, Edificio 17, 90128 Palermo, Italy

3. Institute of Structural and Molecular Biology and Department of Biological Sciences, School of Science, Birkbeck University of London, Malet Street, London WC1E 7HX, UK

4. Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands

5. Catalysis Research Center & Department of Chemistry, Chair of Inorganic and Metal-Organic Chemistry, Technical University of Munich, Ernst-Otto-Fischer Str. 1, D-85748 Garching b. München, Germany

6. School of Pharmacy and Pharmaceutical Sciences, Cardiff University, CF10 3NB Cardiff, Wales, UK

7. Munich Data Science Institute, Technical University of Munich, D-85748 Garching b. München, Germany

Abstract

Self-assembled [Pd2L4]4+ metallacages are promising novel drug delivery systems for anticancer drugs. Their exo-functionalisation with BODIPY moieties enabled the investigation of their uptake mechanisms in cancer cells by confocal microscopy.

Funder

Technische Universität München

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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