Introduction of a tailor made anion receptor into the side chain of small peptides allows fine-tuning the thermodynamic signature of peptide–DNA binding
Author:
Affiliation:
1. Institute for Organic Chemistry
2. University of Duisburg-Essen
3. Essen
4. Germany
5. Institute for Biology
Abstract
Replacing lysine by a tailor made anion binding motif, switches the DNA binding of small peptides from entropy to enthalpy control.
Funder
Deutsche Forschungsgemeinschaft
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01584K
Reference30 articles.
1. Thermodynamics guided lead discovery and optimization
2. Applying thermodynamic profiling in lead finding and optimization
3. Is there a link between selectivity and binding thermodynamics profiles?
4. Entropy-Enthalpy Compensation: Role and Ramifications in Biomolecular Ligand Recognition and Design
5. Binding Thermodynamics of Statins to HMG-CoA Reductase
Cited by 10 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Surfactant like peptides for targeted gene delivery to cancer cells;Biochemical and Biophysical Research Communications;2023-04
2. Rationally designed cationic amphiphilic peptides for selective gene delivery to cancer cells;International Journal of Pharmaceutics;2022-04
3. Triazole groups as biomimetic amide groups in peptides can trigger racemization;Arkivoc;2021-03-11
4. Diverse Properties of Guanidiniocarbonyl Pyrrole-Based Molecules: Artificial Analogues of Arginine;Accounts of Chemical Research;2019-05-31
5. Starburst Diblock Polyprodrugs: Reduction-Responsive Unimolecular Micelles with High Drug Loading and Robust Micellar Stability for Programmed Delivery of Anticancer Drugs;Biomacromolecules;2019-01-18
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3