Reprogramming the metabolism of oleaginous yeast for sustainably biosynthesizing the anticarcinogen precursor germacrene A-Reference-Cited by-同舟云学术

Reprogramming the metabolism of oleaginous yeast for sustainably biosynthesizing the anticarcinogen precursor germacrene A

Published:2023 Issue:20 Volume:25 Page:7988-7997
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Liu Qi¹²³,Zhang Ge²³,Su Liqiu²³,Liu Pi²³,Jia Shiru¹,Wang Qinhong²³,Dai Zongjie²³^ORCID

Affiliation:

1. College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China

2. Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China

3. National Technology Innovation Center of Synthetic Biology, Tianjin 300308, China

Abstract

The highest titer of the anticancer precursor sesquiterpene germacrene A was observed in oleaginous yeast using multi-layered systematic metabolic engineering strategies.

Funder

Chinese Academy of Sciences

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/GC/D3GC01661G

Reference59 articles.

1. Metabolic engineering strategies for sesquiterpene production in microorganism

2. Germacrene A–A Central Intermediate in Sesquiterpene Biosynthesis