Antileishmanial evaluation of triazole–butenolide conjugates: design, synthesis, <i>in vitro</i> screening, SAR and <i>in silico</i> ADME predictions-Reference-Cited by-同舟云学术

Antileishmanial evaluation of triazole–butenolide conjugates: design, synthesis, in vitro screening, SAR and in silico ADME predictions

Published:2023 Issue:6 Volume:14 Page:1131-1142
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Pandey Alka Raj¹²,Singh Suriya Pratap¹,Ramalingam Karthik³,Yadav Kanchan⁴^ORCID,Bisen Amol Chhatrapati⁵⁶,Bhatta Rabi Sankar⁵⁶^ORCID,Srivastava Mrigank⁴,Tripathi Renu⁴,Goyal Neena³,Sashidhara Koneni V.¹²⁶^ORCID

Affiliation:

1. Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, U.P, India

2. Sophisticated Analytical Instrument Facility & Research, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, U.P, India

3. Division of Biochemistry and Structural Biology, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, U.P, India

4. Division of Molecular Microbiology and Immunology, CSIR-Central Drug Research Institute, Lucknow 226031, U.P, India

5. Pharmaceutics and Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow 226031, U.P, India

6. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, U.P, India

Abstract

Synthesis of a novel series of 23 triazole–butenolide conjugates utilizing click chemistry and their antileishmanial, antimalarial, and antifilarial activity along with SAR, ADME predictions and pharmacokinetic study are discussed.

Funder

Department of Science and Technology, Ministry of Science and Technology, India

Indian Council of Medical Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D2MD00464J

Reference24 articles.

1. In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition

2. Leishmaniasis: current situation and new perspectives