Enzyme mediated incorporation of zirconium-89 or copper-64 into a fragment antibody for same day imaging of epidermal growth factor receptor-Reference-Cited by-同舟云学术

Enzyme mediated incorporation of zirconium-89 or copper-64 into a fragment antibody for same day imaging of epidermal growth factor receptor

Published:2021 Issue: Volume: Page:
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Rudd Stacey E.¹²³⁴,Van Zuylekom Jessica K.⁵⁶⁷⁴^ORCID,Raicevic Anna⁸³⁴,Pearce Lesley A.⁸³⁴,Cullinane Carleen⁵⁶⁷⁴⁹,Williams Charlotte C.⁸³⁴,Adams Timothy E.⁸³⁴,Hicks Rodney J.⁹¹⁰³⁴,Donnelly Paul S.¹²³⁴^ORCID

Affiliation:

1. School of Chemistry and Bio21 Molecular Science

2. Biotechnology Institute University of Melbourne

3. Parkville

4. Australia

5. Research Division

6. Peter MacCallum Cancer Centre

7. Melbourne

8. CSIRO Manufacturing

9. Sir Peter MacCallum Department of Oncology

10. University of Melbourne

Abstract

Enzymatic bioconjugation to introduce positron-emitting radionuclides (⁸⁹Zr, ⁶⁴Cu) into an anti-EGFR antibody fragment allows same day imaging with positron emission tomography.

Funder

Australian Research Council

National Health and Medical Research Council

Australian Cancer Research Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC01422F

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1. Untangling the ErbB signalling network