Is it possible to reverse aged acetylcholinesterase inhibited by organophosphorus compounds? Insight from the theoretical study-Reference-Cited by-同舟云学术

Is it possible to reverse aged acetylcholinesterase inhibited by organophosphorus compounds? Insight from the theoretical study

Published:2016 Issue:14 Volume:18 Page:9838-9846
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

An Yun¹²³⁴⁵,Zhu Yali⁶⁷⁸⁹⁵,Yao Yuan¹²³⁴⁵,Liu Junjun⁶⁷⁸⁹⁵

Affiliation:

1. Institute of Theoretical and Simulational Chemistry

2. Academy of Fundamental and Interdisciplinary Science

3. Harbin Institute of Technology

4. Harbin

5. P. R. China

6. School of Pharmacy

7. Tongji Medical College

8. Huazhong University of Science and Technology

9. Wuhan

Abstract

The reaction mechanism for reversing an aged sarin–AChE adduct has been uncovered for the design of detoxification agents against organophosphorus compounds.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CP/C5CP07991H

Reference54 articles.

1. Organophosphate poisoning

2. Structural bases for the specificity of cholinesterase catalysis and inhibition

3. Application of gas chromatography-mass spectrometry and gas chromatography-tandem mass spectrometry to the analysis of chemical warfare samples, found to contain residues of the nerve agent sarin, sulphur mustard and their degradation products

4. Retrospective Detection of Exposure to Organophosphorus Anti-Cholinesterases: Mass Spectrometric Analysis of Phosphylated Human Butyrylcholinesterase

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