Tryptanthrin derivative copper(ii) complexes with high antitumor activity by inhibiting telomerase activity, and inducing mitochondria-mediated apoptosis and S-phase arrest in BEL-7402-Reference-Cited by-同舟云学术

Tryptanthrin derivative copper(ii) complexes with high antitumor activity by inhibiting telomerase activity, and inducing mitochondria-mediated apoptosis and S-phase arrest in BEL-7402

Published:2018 Issue:18 Volume:42 Page:15479-15487
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Qin Qi-Pin¹²³⁴⁵^ORCID,Zou Bi-Qun⁴⁵³⁶⁷^ORCID,Tan Ming-Xiong¹²³^ORCID,Wang Shu-Long¹²³⁴⁵,Liu Yan-Cheng⁴⁵³^ORCID,Liang Hong⁴⁵³

Affiliation:

1. Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology, School of Chemistry and Food Science, Yulin Normal University, 1303 Jiaoyudong Road

2. Yulin 537000

3. P. R. China

4. State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, 15 Yucai Road

5. Guilin 541004

6. Department of Chemistry, Guilin Normal College, 21 Xinyi Road

7. Gulin 541001

Abstract

Try-Cu exhibited its antitumor activity mainly via inhibiting telomerase by interaction with the c-myc promoter and disrupting mitochondrial functions.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangxi Province

Ministry of Science and Technology of the People's Republic of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/NJ/C8NJ03005G

Reference60 articles.

1. G-quadruplex DNA targeted metal complexes acting as potential anticancer drugs